As compared with conventional treatment, intensive treatment reduced the risk of any predefined cardiovascular disease outcome by 42 percent (95 percent confidence interval, 9 to 63 percent; P = 0.02) (Panel A) and reduced the risk of the first occurrence of nonfatal myocardial infarction, stroke, or death from cardiovascular disease by 57 percent (95 percent confidence interval, 12 to 79 percent; P = 0.02) (Panel B).