Table 1.
Examples of stimuli that activate PLCs, increase intracellular Ca2+, and activate CCE
| Ligand | Receptor |
|---|---|
| Due to activation of PLCβ enzymes | |
| Mediated by Gi-type G proteins (pertussis toxin-sensitive) | |
| FMLP | FMLP |
| Interleukin 8 | IL-8 |
| Mediated by Gq-type G proteins (pertussis toxin-insensitive) | |
| Epinephrine | α1-Adrenergic |
| Acetylcholine | M1, M3, M5 |
| Serotonin (5-HT) | 5-HT2a, 2c |
| Histamine | H1 |
| ATP | Pu, Py |
| Arg-vasopressin | V1a, V1b |
| Oxytocin | OT |
| Angiotensin II | AT1 |
| Bradykinin | BK2 |
| Thromboxane | TP |
| Prostaglandin F2α | FP |
| Endothelin | ET-1, ET-2 |
| Colecystokinin | CCK-A |
| Gastrin | CCK-B |
| Gastrin-release peptide (bombesin) | GRP |
| Thyrotropin releasing hormone | TRH |
| Gonadotropin releasing hormone | GnRH |
| Mediated by either Gi- or Gq-type G proteins | |
| Thrombin | Thrombin |
| Platelet activating factor | PAF |
| Due to activation of PLCγ via tyrosine phosphorylation | |
| Antigen | T-cell receptor |
| B-cell receptor | |
| Epidermal growth factor | EGF |