Fig. 4.
Effect of primary alcohols on depolarization-induced insulin secretion. (A) MIN6 cells were preincubated with the indicated concentration of the primary alcohols 1-butanol (1-BuOH) and ethanol (EtOH) or the control secondary alcohols 2-butanol (2-BuOH) and 2-propanol (2-Prop) for 1 h. The amount of insulin secreted in 1 h in response to depolarization in the continued presence of the alcohols was then determined. (B) The pattern of insulin secretion in response to depolarization after treatment, as in A, with the indicated concentrations of 1-butanol and 2-propanol, was determined.