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. Author manuscript; available in PMC: 2009 Feb 10.
Published in final edited form as: J Neurophysiol. 2006 Jul 19;96(5):2364–2376. doi: 10.1152/jn.00523.2006

FIG. 8. 4-AP lowered the threshold of both low- and high-threshold neurons and shifted their sensitive ranges to lower frequencies.

FIG. 8

A: representative example of the 4 of 19 cells in which 4-AP induced spontaneous firing (Cell 20040114C, P3). Arrow indicates addition of 4-AP. B: 4-AP lowered the threshold and induced multiple action potentials in low-threshold neurons (control: black, 4-AP: gray, Cell 20030702D, P2). C: 4-AP had similar effects on high-threshold neurons (control: black, 4-AP: gray, Cell 20030731A, P2). D and E: tuning curves for low- (D) and high- (E) threshold neurons. In both cases, 4-AP lowered the threshold. Interestingly, both low- and high-threshold neurons behaved as low-pass filters in the presence of 4-AP (Low-threshold: Cell 20031113B, P3; high-threshold: Cell 20030709C, P3).