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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Surgery. 2008 Dec;144(6):956–962. doi: 10.1016/j.surg.2008.08.027

Figure 1.

Figure 1

HDAC inhibitor treatment upregulates Notch1 in pheochromocytoma cells. Treatment for 2 days with increasing concentrations of VPA and SBHA increases the amount of active, cleaved Notch1 protein (NICD). The downstream target achaete scute complex-like 1 (ASCL1) also decreased with treatment. GAPDH is shown as a loading control. VPA, valproic acid, SBHA, suberoyl bis-hydroxamic acid, GAPDH, glyceraldehyde 3-phosphate dehydrogenase.