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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Surgery. 2008 Dec;144(6):956–962. doi: 10.1016/j.surg.2008.08.027

Figure 2.

Figure 2

Treatment with HDAC inhibitors increases the amount of active Notch1 as measured by relative luciferase activity. After 2 days of treatment with 8 mM VPA and 40 µM SBHA, an approximately 3-fold induction of Notch1 activity was observed. The increase was statistically significant (P < 0.001, independent samples T test). The experiment was performed in triplicate. VPA, valproic acid. SBHA, suberoyl bis-hydroxamic acid.