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The mechanism of growth inhibition by VPA and SBHA is apoptosis. PC-12 cells were treated with the indicated concentrations of HDAC inhibitors for 2 days, and total cell lysates were prepared. An increase in the cleavage of these two proteins suggests that apoptosis induced cell death. GAPDH was used as a loading control. VPA, valproic acid, SBHA, suberoyl bis-hydroxamic acid, GAPDH, glyceraldehyde 3-phosphate dehydrogenase.
