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End-product feedback regulation of SREBP-1 by endogenously synthesized PUFAs. Insulin activation of SREBP-1c transcription requires intact LXR binding sites in the promoter of the SREBP-1c. SREBP-1c transcriptionally activates genes required for the synthesis of monounsaturated fatty acids and PUFAs. PUFAs feedback and reduce the amount of nuclear SREBP-1 in the cell. ACC, acetyl-CoA carboxylase; ACL, ATP citrate lyase; FAS, fatty acid synthase; SCD, stearoyl-CoA desaturase.
