TABLE 1.
Phenotypic comparison of wild-type and Elovl5−/− mice
| Parameter | Elovl5+/+ | Elovl5−/− | Elovl5+/+ | Elovl5−/− |
|---|---|---|---|---|
| Sex | Male | Male | Female | Female |
| Age (weeks) | 8–9 | 8–9 | 8–9 | 8–9 |
| Number of mice | 10 | 10 | 10 | 10 |
| Body weight (g) | 26.7 ± 1.4 | 24.9 ± 0.6 | 21.6 ± 0.5 | 20.8 ± 0.7 |
| Liver weight (g) | 1.53 ± 0.13 | 1.34 ± 0.05 | 1.08 ± 0.04 | 1.09 ± 0.05 |
| Liver weight/Body weight (%) | 5.66 ± 0.25 | 5.37 ± 0.16 | 5.00 ± 0.11 | 5.27 ± 0.15 |
| Liver cholesterol (mg/g) | 2.5 ± 0.1 | 2.6 ± 0.1 | 2.9 ± 0.1 | 3.9 ± 0.2a |
| Liver triglyceride (mg/g) | 7.1 ± 0.3 | 11.4 ± 1.4a | 14.5 ± 1.1 | 34.2 ± 3.6a |
| Plasma cholesterol (mg/dl) | 97 ± 4 | 100 ± 7 | 88 ± 5 | 79 ± 6 |
| Plasma triglycerides (mg/dl) | 106 ± 9 | 102 ± 16 | 93 ± 8 | 91 ± 9 |
Mice were fed a chow diet ad libitum. Each value represents the mean ± SE.
a
P < 0.05 using Student's t-test.