Fig. 4.

The ratio of liver weight to body weight, body weight loss, liver function test, and survival rate in wild-type and S1P₂^−/− mice in acute liver injury induced by DMN. A single injection of DMN was performed in wild-type (WT) and S1P₂^−/− mice. The ratio of liver weight to body weight (A), body weight loss (B), and serum concentration of ALT (C) and ALP (D) were measured at 48 h after DMN injection. Columns and bars represent means ± SEM of four animals. Survival rate was also determined in wild-type (n = 17) and S1P₂^−/− (n = 16) mice up to 120 h after DMN injection (E). Significantly higher survival rate in S1P₂^−/− mice was determined at 96 and 120 h after DMN injection in Fisher's exact test (P < 0.05).