Fig. 6.

The ratio of liver weight to body weight and body weight loss in wild-type and S1P₂^−/− mice after chronic CCl₄ administration. CCl₄ injection was performed for 4 weeks in wild-type (WT) and S1P₂^−/− mice. The ratio of liver weight to body weight was measured at euthanization after CCl₄ treatment (A). The alteration of body weight was determined by comparison of body weight at the first administration of CCl₄ and at euthanization after the last administration of CCl₄ (B). Columns and bars represent means ± SEM of five animals. The asterisk indicates a significant difference from wild type in Student's t-test (P < 0.05).