TABLE 3.

Associations between ABCG5/G8 haplotypes and plasma HDL-C concentrations

	Polymorphism
Haplotype	G5_i7892T>C	G8_5U145A>C	G8_Tyr54CysA>G	G8_Thr400LysC>A	Frequencya	Coefficient βb	P
H1	T	A	A	C	0.36	−0.53	0.766
H2	C	C	G	C	0.24	−3.43	0.002
H3	T	A	A	A	0.22	1.94	0.014
H4	C	A	A	C	0.06	5.25	0.012
H5	T	C	A	C	0.06	−3.47	0.073
H6	T	A	G	C	0.03	1.18	0.805
H7	T	C	G	C	0.02	−1.89	0.510

HDL-C, HDL-cholesterol; G5, ABCG5; G8, ABCG8. P values were adjusted for age, sex, BMI, physical activity, smoking habit, alcohol consumption, medications, prior coronary heart disease, and population admixture. These haplotypes showed global association with HDL-C levels at P = 0.007 after permutation correction for multiple tests. Boldface type indicates statistically significant (P < 0.05).

^aHaplotype frequencies were estimated using the expectation-maximization algorithm (25).

^bCoefficients and P values were estimated based on haplotype trend regression analysis implemented in the HelixTree program.