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. 2008 Sep 24;28(39):9769–9789. doi: 10.1523/JNEUROSCI.2137-08.2008

Figure 4.

Figure 4.

Eight generalized connexin/connexon configurations proposed to occur within neuronal gap junctions. A, B, Homomeric homotypic Cx36-to-Cx36 channels (A) and Cx45-to-Cx45 channels (B). C, Cx36 in the top cell and Cx45 in the bottom cell, with Cx36 linking to Cx45 (“homomeric heterotypic”). D, Cx43 in the top cell and Cx45 in the bottom cell, with Cx43 linking to Cx45 (“homomeric heterotypic”). E, Both Cx36 and Cx45 in both cells, with Cx36 linked only to Cx36 and Cx45 linked only to Cx45 (“homomeric bihomotypic). F, Both Cx36 and Cx45 in both cells, with both connexins on one side linked to both connexins on the other side (”homomeric biheterotypic“). G, Cx36 only in the top cells linking to connexons containing a mixture of Cx36/Cx45 in the bottom cell (homomeric to heteromeric channels). H, Each connexon contains both Cx36 and Cx45 (heteromeric connexons), linking to heteromeric connexons in the other cell (heteromeric to heteromeric channels).