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(A) Protocol for producing parthenogenetic embryos homozygous or wild type for the mutant p57kip2 or Igf2r. (B) Loss of either p57kip2 or Igf2r in P-MEFs enhances their rates of proliferation, and loss of Igf2r, but not p57kip2 loss, affects BP-MEF proliferation (data not shown). (C and D) Igf2r-/- or p57kip2-/- P-MEFs show enhanced long-term proliferation and do not die.
