Figure 1. Morphine attenuates thermal hypoalgesia in adulthood.
MS+CGN animals displayed significantly shorter PWLs compared to SAL+CGN in response to thermal stimulation applied to the (A) uninjured paw [F(3,73)=61.330,p<.0001]; (B) injured paw [F(3,73)=80.066,p<.0001]. (C) MS+CGN animals displayed significantly reduced TFLs compared to SAL+CGN animals [F(3,73)=5.879,p=.0012]. Neonatally injured females displayed significantly longer PWLs compared to males; uninjured paw [F(1,73)=8.912,p=.0039] and injured paw [F(1,73)=16.914,p<.0001]. N=5-15 rats per group/per sex; * significant main effect of treatment; ** significant main effect of sex; male: ■; female: □.
