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. 2003 Nov 3;100(23):13436–13441. doi: 10.1073/pnas.2333111100

Fig. 5.

Fig. 5.

A model for yellow activation in the bristles of y+660gin flies. In a WT chromosome, the 1A-2 insulator (▿) separates the yellow and AS-C regulatory domains and prevents cross-regulation by enhancers (curved black and gray arrows, Top). In the y+660gin allele, the gypsy insulator (▾) interacts with the 1A-2 insulator, allowing bypass of enhancers from the AS-C to activate yellow transcription. The thick arrows indicate the possible participation of additional enhancers in AS-C other than those shown.