Fig. 2.

Most of the rare Dβ1-Jβ2 joints in Eβ-mutant mice are actually Dβ1-Dβ2-Jβ2 rearrangements. PCR assays for Dβ-Jβ rearrangements in thymocytes of wild-type (+/+), Eβ^-/-, Eβ^R/R, and Eβ^R/Rp53^-/- mice were carried out as in Fig. 1C. Rearrangement products were cloned and sequenced. Sequences of Dβ1-Jβ2.7 joints are shown, and the rest is shown in Fig. 6. Germ-line sequences are shown for comparison. N-nucleotides are indicated, and possible P-nucleotides are underlined.