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Premature telomeric erosion in granulocytes of HLA-DR4+ donors. TRF lengths were measured in granulocytes from 39 HLA-DR4+ (•) and 39 HLA-DR4- (○) donors. The age dependency of telomeric loss in both cohorts is indicated by regression lines (dashed line, HLA-DR4+; solid line, HLA-DR4-). Granulocytes from HLA-DR4+ donors had significantly shorter telomeres (P = 0.004). The annual loss during adult life did not differ significantly (P = 0.24).
