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. 2003 Nov 3;100(23):13525–13530. doi: 10.1073/pnas.2233056100

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Copyright © 2003, The National Academy of Sciences

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Fig. 2. — Tissue-specific expression of tph1 and tph2.(A) 5-HT levels in tph1^-/- and tph1^+/+ mice in the brainstem (tph1^-/-, n = 11, and tph1^+/+, n = 8), the pineal gland (tph1^-/-, n = 17, and tph1^+/+, n = 8), the gut (tph1^-/-, n = 10, and tph1^+/+, n = 4), and the blood (tph1^-/-, n = 7, and tph1^+/+, n = 7). Values are expressed as mean ± SEM; ^*, P < 0.05; ^**, P < 0.001 (Student t test) for the difference between tph1^-/- and tph1^+/+ mice. (B) TPH1 and TPH2 mRNAs as revealed by ISH. The TPH1 riboprobe was used in Ba, Bb, and Be; the TPH2 riboprobe was used in Bc and Bd. The β-GAL riboprobe was used in Bf. (Scale bars = 1 mm.)