Table 4.
Lipoprotein particle concentrations and size in men (Alaska Eskimos ages ≥ 18 years), by tertile of HOMA–IR
| HOMA-IR Index | ||||
|---|---|---|---|---|
| < 1.47 (n = 168) |
1.47–2.40 (n = 168) |
> 2.40 (n = 169) |
P Adjusted* | |
| VLDL (nmol/L) | ||||
| Large | 0.7 ± 1.6 | 1.0 ± 1.8 | 1.4 ± 2.7 | 0.28 |
| Intermediate | 13.4 ± 11.1 | 17.0 ± 13.1 | 18.4 ± 12.0 | 0.21 |
| Small | 40.5 ± 17.9 | 44.7 ± 20.3 | 45.6 ± 18.9 | 0.05 |
| VLDL size (nm) | 41.9 ± 8.5 | 45.9 ± 9.4 | 47.3 ± 10.1 | <0.0002 |
| LDL (nmol/L) | ||||
| Large | 489 ± 162 | 511 ±175 | 479 ± 187 | 0.36 |
| Intermediate | 99 ± 50 | 112 ± 65 | 146 ± 82 | 0.06 |
| Small | 410 ± 208 | 465 ± 260 | 583 ± 307 | 0.37 |
| LDL size (nm) | 21.5 ± 0.5 | 21.4 ± 0.6 | 21.2 ± 0.6 | 0.42 |
| HDL (µmol/L) | ||||
| Large | 6.2 ± 3.9 | 4.8 ± 3.4 | 4.3 ± 3.2 | 0.01 |
| Intermediate | 1.2 ± 3.1 | 1.3 ± 2.4 | 1.7 ± 3.0 | 0.01 |
| Small | 19.7 ± 4.6 | 20.2 ± 4.2 | 20.7 ± 5.1 | 0.79 |
| HDL size (nm) | 9.1 ± 0.5 | 8.9 ± 0.5 | 8.8 ± 0.5 | 0.33 |
Data are mean ± SD.
*
Adjusted for age, BMI, systolic blood pressure, smoking habits, plasma triglycerides (VLDL subfracions), LDL-cholesterol (LDL subfractions), and HDL-cholesterol (HDL subfractions).
Lipoprotein particles were measured using nuclear magnetic resonance.