Figure 7.

Fras1 protein may enhance metanephric initiation via several pathways. (A) Putative network of metanephric effector molecules which may be ultimately regulated by Fras1, an ECM-related protein which coats the surface of the UB. Beyond Fras1 itself, the expression of the molecules are altered in bl/bl renal primordia, as demonstrated in the current paper, and several of them have additionally been shown to regulate other molecules depicted in the scheme. See the main text for details and references cited for this figure.