Table 1.
Acute effects on 45Ca transport by HOM fetuses treated with PTHrP, PTH, or diluent alone
| Treatment |
45Ca/51Cr
activity ratios
|
||
|---|---|---|---|
| Homozygote (n) | Treated homozygote (n) | P value | |
| PTHrP-(1-86) | 75.3 ± 3.3 (20) | 98.9 ± 5.2 (8) | <0.001 |
| PTHrP-(67-86) | 78.1 ± 2.9 (25) | 92.6 ± 5.8 (6) | <0.04 |
| PTHrP-(1-34) | 79.0 ± 4.5 (11) | 69.9 ± 5.6 (7) | NS |
| PTH-(1-84) | 75.0 ± 3.6 (18) | 80.9 ± 4.8 (10) | NS |
| 0.9% saline | 75.1 ± 3.9 (14) | 76.1 ± 2.7 (7) | NS |
All peptides were administered in 1-nmol amounts in an injection volume of 2 μl. The number of observations is indicated in parentheses. For the purpose of comparing data from different litters, the mean 45Ca/51Cr ratios of the untreated heterozygotes of each litter from which these basal and treated homozygote values were obtained have been set at 100%. For further details, see Materials and Methods. NS, not significant.