Figure 2:

Trends in scope of SNP webservers. (a) Prior to 2006, protein-based servers that only handle non-synonymous SNPs were predominant. Newer servers include regulatory SNPs and annotate associations among SNPs through linkage disequilibrium estimates. (b) The earliest servers implemented original computational methods, but the current trend is towards meta-servers and hybrids. Dates associated with each server are based on date of first journal publication, unless an alternate date is documented on its website.