TABLE 9.
Summary on the Effect of DE-71 on THs, Hepatic Protein Activity, and Gene Expressiona
| Target | PND 4 | PND 21 | PND 60 |
| T4 | ↓↓ | ↓↓ | — |
| T3 | — | — | — |
| EROD | ↑↑↑ | ↑↑↑ | — |
| PROD | ↑↑↑ | ↑↑ | — |
| BROD | ↑↑ | ↑↑↑ | — |
| UGT-T4 | ↑ | ↑ | — |
| SULT-T4 | — | — | — |
| D1-T4 | ↓↓↓ | ↓ | — |
| Cyp1a1 | ↑↑↑ | ↑↑↑ | ↑ |
| Cyp2b1 | ↑↑↑ | ↑↑↑ | — |
| Cyp2b2 | ↑↑↑ | ↑↑↑ | — |
| Cyp3a1 | ↑ | ↑↑ | — |
| Ugt1a1 | — | — | — |
| Ugt1a6 | ↑↑ | — | — |
| Ugt1a7 | ↑ | ↑ | — |
| Ugt2b | ↑ | ↑↑ | — |
| Sult1a1 | — | — | — |
| Sult1b1 | — | ↑↑ | — |
| Sult1c1 | — | — | — |
| Mdr1 | ↑↑↑ | ↑↑↑ | — |
| Mrp2 | ↑ | ↑↑↑ | ↓ |
| Mrp3 | ↑↑↑ | ↑↑↑ | — |
| Oatp1a4 | — | ↑ | — |
| Oat2 | — | — | — |
| Ntcp | — | — | — |
| Ttr | — | ↓ | — |
| d1 | ↓↓ | ↓ | — |
Note. Overall hepatic effects after perinatal exposure to the polybrominated diphenyl ether mixture, DE-71 on THs, hepatic protein activity and gene expression. Data was measured in male rat at PND 4, 21, and 60 after perinatal exposure to 0, 1.7, 10.2, and 30.6 mg/kg/day between GD 6 to PND 21.
a
Three, two, and one arrow refers to significant effects at doses 1.7, 10.2, and 30.6 mg/kg/day, respectively.