Fig. 1.

ERG responses in Rpe65^-/- mice increase on dark rearing. (A) Full-field scotopic ERG traces in response to a fixed-light intensity (2.48 photopic m^-2·cd·s) of cyclic-light-reared Rpe65^-/- mice after 1 day (trace a), 1 week (trace b), 2 weeks (trace c), 3 weeks (trace d), and 4 weeks (trace e) of dark rearing. (B) a-waves were plotted on an expanded time base. (C) a-wave amplitude comparisons (n = 22). (D) b-wave amplitude comparisons (n = 22). (E) a-wave amplitude analysis after return of animals to cyclic light (n = 8). Data are presented as means ± SE, the underlines in C-E indicate the time points compared, and ^* indicates a significant difference (one-tailed t test). DA, dark adaptation; CL, cyclic light.