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IL-6 plasma levels are reduced by CR during clinical EAE. Blood samples were obtained at time of sacrifice at Day 30 p.i. from mice fed ad libitum or CR SJL mice. Serum IL-6 levels were measured by ELISA (n=5 for CR; n=9 for controls). IL-6 levels were significantly lower in the CR-treated mice compared with controls (*, P=0.02; two-tailed t-test with Welch’s correction).
