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. Author manuscript; available in PMC: 2009 Feb 10.
Published in final edited form as: Mol Ther. 2008 Jul 1;16(9):1587–1593. doi: 10.1038/mt.2008.140

Figure 6. Estrogen receptor-α (ER-α) contributes to the rapid increase in synaptic transmission after β-estradiol 3-benzoate (EB) application to hippocampal slices.

Figure 6

Time courses for changes in hippocampal synaptic responses after EB application (arrow) in (a) female and (b) male wild-type (WT) (filled circles) and ER-α knockout (ER-αKO) (open circles) mice. The increase in the synaptic response from baseline (dashed line) was reduced in ER-αKO slices relative to WT slices. (c) Examples of synaptic responses obtained during baseline recordings (control) and 30 minutes after application of EB to a hippocampal slice obtained from a WT male mouse. The averages were generated from recordings of 8–13 slices and error bars = SEM. The SEMs are presented for every fifth record to preserve clarity.