Table 3.

Quantitative metrics of thinning by region within 3 additional samples of participants

Region	Mean difference (mm)			Percent thinning			Effect size
Sample	2	3	4	2	3	4	2	3	4
Medial temporal	0.38***	0.36***	0.55***	13.00	12.06	18.68	1.40	1.38	1.54
Inferior temporal	0.14	0.25***	0.10	5.46	9.19	4.08	0.50	1.48	0.41
Temporal pole	0.31***	0.22*	0.32***	12.36	8.03	11.88	1.17	0.93	1.55
Angular	0.09	0.27***	0.21***	4.20	11.91	9.25	0.54	1.42	1.25
Superior frontal	0.11	0.19**	0.32***	4.75	8.03	12.96	0.45	0.98	1.45
Superior parietal	0.18**	0.08	0.08*	10.01	4.20	3.98	1.07	0.41	0.68
Supramarginal	0.20**	0.23**	0.16*	9.18	10.04	6.80	1.09	1.05	0.84
Precuneus	0.10	0.18*	0.16*	5.08	8.40	7.21	0.51	0.97	0.74
Inferior frontal	0.14*	0.13*	0.15***	6.75	5.98	7.10	0.85	0.91	1.16
Primary visual	0.06	0.00	0.03	4.62	0.16	2.28	0.61	0.02	0.25

Note: Effect size = Cohen's d effect size. Regions of significant thinning in AD as compared with OC (*P < 0.05; **P < 0.005; ***P < 0.001).