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. 2008 Nov 24;25(1):1–5. doi: 10.1093/bioinformatics/btn594

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — The KEPE motif in C/EBP transcription factors. (A) The IUPred plot predicts human C/EBPα to be almost entirely natively disordered (the higher the peak, the more disordered). Like the KEPE motif, the leucine zipper (BRLZ) is also predicted as natively disordered (correctly so, since it must dimerise as coiled coil to acquire a stable folded structure). (B) C/EBP KEPE motif: an alignment of the RDM motif from Drosophila C/EBP and four vertebrate paralogues C/EBPα, -β, -δ and -ε (CEBPA, CEBPB, CEBPD and CEBPE) show the conservation of the motif (K is the sumoylated residue).