Table 1.

Enrichment of KEPE motif matches with various term combinations from the KW and/or GO term fields in Swiss-Prot entries

Keywordsa,b	No.	Total	Total	P-value	P-value
	KEPEc	Hd	Sd	He	Se
Homo sapiens	331	18 054	7707	–	–
GO=cytoplasm*!nucleus	35	2303	1146	2.45E−01	2.67E–02
or KW=cytoplasm*!nucleus*
GO=nuclear*|nucleus|	168	3608	1789	2.10E−36	9.41E–29
nucleolus!cytoplasm* or
KW=nuclear*!cytoplasm*
|nucleus!cytoplasm*
Link=znf*	79	1577	799	6.82E−17	4.01E–13
Link=bzip*	17	9	35	7.58E−18	8.62E–15
GO=transcription*	90	1239	627	7.43E−31	2.36E–26
GO=chromatin* or	21	213	139	4.12E−10	4.08E–07
KW=chromatin*
GO:0003700	36	506	264	3.55E−12	4.65E–10
(transcription factor
activity)
GO:0008270	9	164	74	3.32E−03	4.20E–03
(zinc ion binding)
GO:0006355	17	253	131	4.60E−06	4.11E–05
(Regulation of transcription,
DNA-dependent)

^aSearch terms which have been used to retrieve the KEPE sequences.

^bIn Swiss-Prot the annotation ‘cytoplasm’ is used (incorrectly) as a synonym for ‘cytosol’.

^cNumber of sequences matching the KEPE pattern [MLIVTF]K.EP.{1,4}[DE] used in combination with the various search terms.

^dTotal number of sequences (as obtained with the SIRW search tool, in Swiss-Prot release 54.7) matching the search terms shown in the left column. (H): all human sequences; (S): human sequences with the SUMO motif [VILMTF]K.E.

^eThe P-value for the relative enrichment was calculated by the Fisher's exact test from the R package (for total ‘H’ and total ‘S’).