Table II.
Multivariate analysis of the clinicopathological parameters and the subclassification (Clusters AT and BT) based on DNA methylation status of cancerous tissue samples as predictors of recurrence
| Parameters | Hazard ratio (95% CI) | χ2 | P value |
| Histological grade | |||
| Grade 1, 2 or 3 | 1 (Reference) | ||
| Grade 4 | 118.582 (5.186–2711.249) | 8.947 | 0.0028 |
| Macroscopic configuration | |||
| Type 1 | 1 (Reference) | ||
| Type 2 | 5.309 (0.689–40.887) | 2.570 | 0.1089 |
| Type 3 | 0.820 (0.061–11.005) | 0.022 | 0.8808 |
| Vascular involvement | |||
| Negative | 1 (Reference) | ||
| Positive | 1.434 (0.098–20.932) | 0.070 | 0.7920 |
| Renal vein tumor thrombi | |||
| Negative | 1 (Reference) | ||
| Positive | 8.780 (0.429–179.734) | 1.990 | 0.1584 |
| Subclassification based on DNA methylation status | |||
| Cluster AT | 1 (Reference) | ||
| Cluster BT | 8.317 (1.100–62.901) | 4.211 | 0.0402 |
CI, confidence interval.