Table I.
Differential sensitivity to carcinogens across mouse lines
| Straina | Carcinogen | No. of tumors per mouse | References |
| A/J | DMH, AOM | 9.2–41.6 | (26,42,46,254,255) |
| STS/A | DMH | 8.2–18.4 | (56) |
| SWR/J | DMH, AOM | 9.5–16 | (26,41,42,255) |
| FVB/N | AOM | 3.6 | (37) |
| C57Bl/6b | DMH, AOM, MAM acetate | 0–5.5 | (37,41,49,255–257) |
| BALB/cJ | AOM | 1–2 | (24,44,45) |
| ICR/Hac | DMH | n.d. | (41,257) |
| DBA/2J | 3-MC, DMH | 0–1 | (44,256,257) |
| AKR/J | DMH, AOM, MAM | <1.0 | (26,37,38,42,44,46,255) |
| 129/SV | AOM | 0 | (37) |
| BALB/cHeA | DMH | 0 | (56) |
3-MC, methylcholanthrene.
a
Tumor incidence in the most sensitive strain that typically approaches 100%.
b
Tumor incidences in the C57Bl/6 line are dependent upon the particular subline (N, J and Ha), ranging from 10 to 85% (251). n.d., not determined.
c
Incidence was 100%, but total number of tumors per colon was not reported.