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Coordinate control of glycolysis by AMP-activated protein kinase (AMPK). In chronic pressure-overload cardiac hypertrophy in the rat, increased ATP demand signalled as decreased [PCr] leads to an increase in glycolytic flux by two coordinate mechanisms: increasing glucose transport (increasing substrate supply) and activating phosphofructokinase in the glycolytic pathway (increasing utilization), both mediated by AMPK. Redrawn with permission.15
