Table 2.

mRNA Gene Expression Characteristics and Association With Radiographic Disease Response

	Gene Name	Probe set ID	N	Min	Max	Median	Mean	Spearman's rho	p-value
Clinical Response			49	95% (increase)	−100% (decrease)	−19%	−19%
RRM1	regulatory subunit of ribonucleotide reductase	*	35	0.37	7.93	1.68	2.72	0.649	<0.001
RRM2a	catalytic subunit of ribonucleotide reductase	Hs00367247-m1	32	0.00	5.42	0.90	1.38	−0.017	0.924
RRM2b	P53-inducible catalytic subunit of ribonucleotide reductase	Hs00153082-m1	32	0.00	12.24	1.34	1.99	0.276	0.125
DCK	deoxycytidine kinase	Hs00176127-m1	32	0.46	40.39	3.82	5.52	0.130	0.476
CDA	cytidine deaminase	Hs00156401-m1	32	0.00	118.66	2.42	10.27	0.028	0.878
ENT1 (SLC29A1)	equilibration sensitive nucleoside transporter 1	Hs00191940-m1	32	0.00	21.42	1.30	2.18	0.162	0.374
5'-NT (NT5C1A)	cytosolic 5’-nucleotidase	Hs00261369-m1	32	0.00	170843.81	0.00	10.89	−0.081	0.657
TS	thymidylate synthase	Hs00426591-m1	35	0.32	18.31	3.39	4.46	0.454	0.006
DHFR	dihydrofolate reductase	Hs00758822-s1	32	0.00	9.83	0.85	1.29	0.166	0.362
GARFT	phosphoribosylglycinamide formyl transferase	Hs00531926-m1	32	0.17	21.93	1.19	2.28	0.002	0.988
FPGS	folylpolyglutamate synthase	Hs00191956- m1	32	0.36	32.75	2.23	3.50	0.222	0.220
ENT2 (SLC29A2)	equilibration sensitive nucleoside transporter 2	Hs00155426-m1	32	0.11	41.30	5.16	7.76	0.125	0.494
RFC1 (SLC19A1)	reduced folate carrier	Hs00161870-m1	32	0.01	33.47	0.12	2.23	0.096	0.600
γ-GH	gamma-glutamyl hydrolase	Hs00608257-m1	32	0.07	33.52	2.47	5.75	−0.015	0.934

^*5'-FAM-TTTGC TCTTT GGATT CCGGA TCTCT TCA-TAMRA-3’