Figure 6.

Pharmacokinetics of cisplatin. The concentration of cisplatin was measured in blood, cerebrospinal fluid (CSF), and scala tympani perilymph, as indicated, after intravenous administration of cisplatin (5 mg/kg) to guinea pigs (n = 10). The number of samples per time point per treatment is indicated. Data are the mean; error bars are 95% confidence intervals when data from three or more guinea pigs were available. When the lower confidence limit was less than 0, no lower error bar is shown (a logarithmic concentration scale is used). Ten guinea pigs were used for this study.