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. 2008 Oct 30;24(24):2901–2907. doi: 10.1093/bioinformatics/btn562

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Results of fitting SDEs (left) and ODEs (right) in case study 2. Top panel shows the mean reconstructed transcription profile τ(t) using the switch approximation. Middle panel shows results for M_g. Bottom panel gives results for P. Big dots are experimental data for M_g (middle panel) and P (bottom panel). The variation is shown as follows: for SDE approach (left): solid lines in middle and bottom panel give the 5%, mean and 95% values computed from 10 000 simulations of the SDE (using mean posterior parameter estimates). For ODE approach (right): solid lines corresponds to the mean ODE fit (using mean posterior parameter estimates) plus/minus twice the mean posterior standard error.