Table 1.
Effect of R-568 on the development of polycystic kidney disease in PCK rats
| Male | Female | P value | ||||||
|---|---|---|---|---|---|---|---|---|
| Control | 0.05% | 0.1% | Control | 0.05% | 0.1% | Gender | R-568 | |
| (n = 10) | (n = 10) | (n = 10) | (n = 10) | (n = 10) | (n = 10) | |||
| Body weight (g) | 340 ± 19 | 330 ± 20 | 299 ± 27* | 234 ± 10 | 221 ± 15* | 218 ± 10* | < 0.001 | < 0.001 |
| Kidney weight (% BW) | 1.97 ± 0.30 | 1.95 ± 0.20 | 1.85 ± 0.21 | 1.57 ± 0.26 | 1.61 ± 0.20 | 1.63 ± 0.20 | < 0.001 | NS |
| Kidney cyst volume (%) | 22.7 ± 5.4 | 20.2 ± 5.5 | 20.9 ± 2.3 | 21.1 ± 5.6 | 19.3 ± 6.3 | 18.9 ± 4.0 | NS | NS |
| Kidney fibrosis volume (%) | 4.53 ± 1.71 | 2.17 ± 0.92* | 1.58 ± 0.41* | 2.94 ± 1.17 | 1.28 ± 0.57* | 1.03 ± 0.41* | < 0.001 | < 0.001 |
| Kidney cAMP (pmol/mg protein) | 25.2 ± 8.9 | 36.6 ± 12.1 | 33.9 ± 16.7 | 20.8 ± 10.0 | 19.3 ± 5.6 | 17.0 ± 2.7 | < 0.001 | NS |
| Plasma BUN (mg/dL) | 16.1 ± 1.7 | 16.7 ± 2.0 | 20.3 ± 4.6* | 16.4 ± 0.8 | 16.9 ± 2.2 | 16.3 ± 1.6 | NS | 0.031 |
| Plasma osmolality (mosm/L) | 310 ± 10 | 310 ± 14 | 306 ± 16 | 318 ± 13 | 309 ± 10 | 310 ± 8 | NS | NS |
| Plasma phosphorus (mg/dL) | 8.4 ± 1.0 | 10.4 ± 1.5* | 12.5 ± 1.4* | 7.4 ± 0.7 | 9.9 ± 1.3* | 11.1 ± 0.9* | 0.003 | < 0.001 |
| Plasma calcium (mg/dL) | 10.3 ± 0.4 | 8.4 ± 0.4* | 8.1 ± 0.5* | 10.6 ± 0.2 | 8.6 ± 0.4* | 8.1 ± 0.2* | 0.025 | < 0.001 |
| Urine volume (μL/min) | 8.3 ± 2.4 | 14.2 ± 2.0* | 13.5 ± 1.6* | 4.0 ± 0.5 | 10.0 ± 2.0* | 10.1 ± 1.5* | < 0.001 | < 0.001 |
| Urine osmolality (mosm/L) | 869 ± 391 | 863 ± 413 | 1064 ± 420 | 1785 ± 577 | 1795 ± 523 | 1840 ± 352 | < 0.001 | NS |
| Osmolar clearance (μL/min) | 21.3 ± 7.9 | 38.7 ± 17.3* | 48.1 ± 21.6* | 22.3 ± 7.9 | 55.6 ± 11.4* | 60.0 ± 14.5* | 0.009 | < 0.001 |
| Free water clearance (μL/min) | −13.0 ± 9.4 | −24.4 ± 17.9 | −34.6 ± 20.5* | −18.3 ± 7.7 | −45.6 ± 12.2* | −49.9 ± 13.8* | < 0.001 | < 0.001 |
| Urine sodium (mEq/24 h) | 0.56 ± 0.22 | 3.03 ± 0.37* | 2.54 ± 0.88* | 0.42 ± 0.15 | 2.02 ± 0.48* | 2.22 ± 0.54* | < 0.001 | < 0.001 |
| Urine potassium (mEq/24 h) | 2.02 ± 0.71 | 5.44 ± 0.86* | 5.01 ± 0.85* | 1.43 ± 0.29 | 3.58 ± 0.93* | 4.28 ± 0.99* | < 0.001 | < 0.001 |
| Urine phosphorus (mg/24 h) | 18.2 ± 8.4 | 13.5 ± 4.2 | 8.6 ± 7.7* | 13.8 ± 4.2 | 8.5 ± 4.8* | 9.0 ± 1.7* | NS | 0.002 |
| Urine calcium (mg/24 h) | 1.04 ± 0.63 | 2.27 ± 0.87* | 5.48 ± 2.00* | 0.79 ± 0.41 | 3.02 ± 0.95* | 4.30 ± 0.92* | NS | < 0.001 |
*P < 0.01 versus control.