Table 1.
Relationship between hazard ratio for CHD, AUC and the C-statistic for CRP, established risk predictors, the Framingham risk score and the Framingham risk score and CRP combined in NPHS II and EAS
| NPHS-II |
EAS |
|||||
|---|---|---|---|---|---|---|
| Hazard ratioa (95%CI) | AUC (95%CI) | C-indexb (95%CI) | Hazard ratioa (95%CI) | AUC (95%CI) | C indexb (95%CI) | |
| CRP | 2.53 | 0.61 | 0.63 | 1.87 | 0.62 | 0.59 |
| (1.44–4.62) | (0.57–0.66) | (0.60–0.66) | (1.21–2.89) | (0.57–0.67) | (0.54–0.63) | |
| SBP | 1.96 | 0.60 | 0.59 | 2.00 | 0.62 | 0.58 |
| (1.10–3.50) | (0.55–0.64) | (0.56–0.62) | (1.39–2.89) | (0.58–0.66) | (0.54–0.62) | |
| TC | 1.35 | 0.59 | 0.59 | 1.91 | 0.62 | 0.55 |
| (0.75–2.43) | (0.55–0.64) | (0.56–0.62) | (1.32–2.76) | (0.58–0.66) | (0.51–0.59) | |
| HDL-C | 0.74 | 0.57 | 0.58 | 0.56 | 0.61 | 0.61 |
| (0.55–0.99) | (0.50–0.65) | (0.53,0.62) | (0.37–0.84) | (0.57–0.65) | (0.57–0.64) | |
| FRS | 1.47 | 0.62 | 0.62 | 4.61 | 0.65 | 0.68 |
| (0.68–3.18) | (0.57–0.66) | (0.60–0.65) | (2.98–7.13) | (0.61–0.70) | (0.64–0.71) | |
| FRS+CRP | 2.11 | 0.64 | 0.66 | 3.67 | 0.65 | 0.67 |
| (1.04–4.31) | (0.60–0.69) | (0.63–0.68) | (2.16–6.23) | (0.61–0.70) | (0.63–0.71) | |
Framingham variables used in NPHS-II were age, smoking, SBP, cholesterol, diabetes.
Framingham variables used in EAS were age, sex, smoking, SBP, cholesterol, HDL, diabetes.
aHazard ratio for top vs bottom tertile adjusted for age, practice, blood pressure, total- and HDL- cholesterol where appropriate.
bPredictive accuracy is calculated as Harrell's C-index, which extends the AUC to the case of right-censored survival data.