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Function of atria isolated from control rats and rats with heart failure. (A) Spontaneous beating rate. *P < 0.05 vs. Control. (B) Effect of L-NAME on basal beating rate in control and failing hearts. *P < 0.05 vs. vehicle. (C and D) Effect of L-NAME on isoproterenol-stimulated beating rate of isolated atria from control and failing hearts. *P < 0.05 vs. −L-NAME; n = 5 per group.
