Fig. 2.

Effect of doxycycline on growth of laminin-α2-deficient, Lama2^-/- mice. At 3.5 and 6 weeks after birth, male Lama2^-/- mice that were treated with doxycycline (green bars) weighed significantly more than male Lama2^-/- mice that were not treated (red bars). Though doxycycline-treated female Lama2^-/- mice were significantly larger than untreated Lama2^-/- mice at 3.5 weeks, no difference was found at 6 weeks. At both ages, the doxycycline-treated male and female Lama2^-/- mice remained significantly smaller than untreated wild-type (gray bars) littermates (P < 0.01 or better for all comparisons of wild-type to Lama2^-/- mice). Treatment with doxycycline did not affect the weights of wild-type mice (not shown). **Weights of untreated and doxycycline-treated Lama2^-/- mice were significantly different at P<0.01 by student's t-test; n.s. Weights of untreated and minocycline-treated Lama2^-/- mice were not significantly different. Ave. ± SE, n as indicated.