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Doxcycline treatment improved motor behavior in Lama2-/- mice. Exploratory behavior, measured by the number of times the mice stood up on their hindlegs during the first five minutes in a new cage, was significantly decreased in 6 week old Lama2-/- mice (red bar, n = 9) compared to wild-type mice (WT, gray bar, n = 5). Doxycycline-treated Lama2-/- mice (green bar, n = 8) showed exploratory behavior that was near wild-type. Error bars = SE. ** P < 0.01 by t-test.
