Table 3. FTO rs9939609 (genotype TT vs. TA and AA) and all-cause mortality in 1,628 Danish men.

		Obese			Random sample			Pooled
	N	HR	95% CIs	P value	HR	95% CIs	P value	HR	95% CIs	P value
Crude	1,628	0.51	0.29–0.90	0.02	0.62	0.40–0.97	0.04	0.58*	0.41–0.82	0.001
Adjusted for BMI S-46	1,626	0.52	0.29–0.91	0.02	0.61	0.39–0.95	0.03	0.58*	0.41–0.82	0.002
Adjusted for BMI and waist S-46	1,624	0.51	0.29–0.91	0.02	0.59	0.38–0.92	0.02	0.57*	0.40–0.81	0.002
Adjusted for BMI S-20 and S-46	1,626	0.53	0.30–0.94	0.03	0.61	0.39–0.96	0.03	0.59*	0.41–0.83	0.003
Adjusted for fat-BMI S-46	1,523	0.59	0.33–1.05	0.07	0.64	0.41–1.01	0.06	0.63*	0.44–0.90	0.01

Cox proportional hazards analysis with age as the underlying time scale and delayed entrance at age at time of blood sampling (S-46). There was no interaction between the genotypes and the original sampling variable (Random sample vs. obese)

Abbreviations: BMI, body mass index; fat-BMI, fat mass (kg)/height² (m²); N, number of subjects with complete covariate information; HR, Hazard ratio; CI, Confidence interval; S-20, draftee population of median age 20; S-46, follow-up survey at median age 46

^*p<0.05 for the likelihood ratio test (Likelihood ratio tests were used to estimate whether a model including both fatness-covariates and FTO rs9939609 fitted the data better than a model including only fatness-covariates)