Figure 3.

Pharmacological remodeling of human atrial cell electrophysiology by β₁-blocker therapy. A: APs and ERP (↔); B: mean (±standard error) APD at 50% and 90% repolarization (APD₅₀ and APD₉₀) and ERP; C: transient outward K⁺ currents, recorded in single atrial myocytes from patients in SR, treated with a β₁-blocker ≥7 days (solid symbols) versus those in SR who were not treated with a β-blocker (open symbols). *P <.05 versus non β-blocker. D: Correlation between atrial cell ERP and patient's atenolol dose/body weight. Heart rate ≤75 bpm. Dashed lines indicate the 95% confidence interval. Panels A and C are based on data in reference 31 with permission from Elsevier.