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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2008 Nov 1;16(24):10270–10280. doi: 10.1016/j.bmc.2008.10.048

Scheme 1.

Scheme 1

Reagents and conditions: (i) BnBr, K2CO3, EtOH, reflux, 16 h; 95%; (ii) CH3NO2, NH4OAc, 70 °C, 14 h; 75%; (iii) LiAlH4, THF, reflux, 4 h; (iv) (Boc)2O, Et3N, CH3CN, rt, overnight; 76% (2 steps); (v) H2, Pd/C, EtOH, rt, 5 h; 66%.