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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2008 Nov 1;16(24):10270–10280. doi: 10.1016/j.bmc.2008.10.048

Table 3.

Antiviral activity and cytotoxicity assaya results for 6a–o against HIV-1 (IIIB) in MT-2 cell culture.

R EC50b (μM) CC50c (μM) T.Id R EC50b (μM) CC50c (μM) T.Id
CH3 HI-236 0.048 1.0 21 graphic file with name nihms88222t15.jpg 6h 2.0 5.8 3
graphic file with name nihms88222t16.jpg 6a 0.095 0.1 1 graphic file with name nihms88222t17.jpg 6i 0.095 9.5 100
graphic file with name nihms88222t18.jpg 6b 0.052 0.1 2 graphic file with name nihms88222t19.jpg 6j 0.39 6.8 17
graphic file with name nihms88222t20.jpg 6c 0.026 1 38 graphic file with name nihms88222t21.jpg 6k 12 48 4
graphic file with name nihms88222t22.jpg 6d 0.25 10.0 40 graphic file with name nihms88222t23.jpg 6l 0.12 5.5 46
graphic file with name nihms88222t24.jpg 6e 0.27 20.0 74 graphic file with name nihms88222t25.jpg 6m 0.05 3.8 76
graphic file with name nihms88222t26.jpg 6f 0.20 11.0 55 graphic file with name nihms88222t27.jpg 6n 0.012 1.0 83
Bn 6g 0.22 4.0 18 graphic file with name nihms88222t28.jpg 6o 0.098 8.5 94
a

Ref. 19; MOI was 0.1.

b

Effective concentration that inhibits viral-mediated T-cell death by 50%, determined by averaging samples of each concentration in triplicate.

C

Concentration that kills 50% of the T-cells, also determined by averaging triplicate samples.

d

In vitro therapeutic index (CC50/EC50).