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. Author manuscript; available in PMC: 2009 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2008 Nov 1;16(24):10270–10280. doi: 10.1016/j.bmc.2008.10.048

Table 4.

Comparison of cell culture versus in vitro RT inhibition (nM) for selected derivatives of 6.

graphic file with name nihms88222f12.jpg
R Antiviral activity EC50 (nM) RT inhibition assay IC50 (nM) Antiviral activity Y181C EC50 (nM) Cellular Toxicity Y181C CC50 (TI) (nM)
Me (HI-236) 48 28 1200 18,000 (15)
graphic file with name nihms88222t29.jpg 6c 26 3.8 <200 4000 (>20)
graphic file with name nihms88222t30.jpg 6d 250 27
graphic file with name nihms88222t31.jpg 6i 95 41
graphic file with name nihms88222t32.jpg 6k 12,000 100
graphic file with name nihms88222t33.jpg 6n 12 19
graphic file with name nihms88222t34.jpg 6o 98 24