TABLE 2.

Mouse Models of Arsenic-induced CVD via Drinking Water Arsenic Exposure

Reference	Mouse strain	Arsenic exposure and level	End point assayed and outcome
Bunderson et al. (2004)	ApoE, LDLr double knockout	Drinking water, 5.7 mg/l, 18 weeks	Increased atherosclerotic plaque stenosis in innominate artery
Simeonova et al. (2003)	ApoE-knockout	Drinking water, 11.4 or 57 mg/l, 24 weeks	Increased aortic lesions
Srivastava et al. (2007)	ApoE-knockout	Transplacental in drinking water, 49 mg/l, gestational days 8–18	Increased fatty streak lesions in aortic arch and valves, defective vasorelaxation response at age 10 weeks
Straub et al. (2007a,b)	C57Bl/6	Drinking water, 250 μg/l, 5 weeks	Liver sinusoidal capillarization, angiogenesis in liver bile ducts, decreased lumen in hepatic arterioles, gain in sinusoidal endothelial cell caveolin and caveolae
Straub et al. (2008)	C57Bl/6 p47phox knockout	Drinking water, 10–250 μg/l, 2 weeks	Liver sinusoidal capillarization, loss of modified albumin scavenging, protein nitration, oxidant generation, absence of arsenic-induced effects in knockout