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. 2008 Aug 20;28(34):8430–8441. doi: 10.1523/JNEUROSCI.2752-08.2008

Figure 4.

Figure 4.

A, B, 17β-Estradiol prevents cerebral ischemia-induced elevation of p-β-catenin levels in nuclear fraction of hippocampus CA1 after global cerebral ischemia. Values are mean ± SEM of determinations from five to six individual rats expressed as fold change versus sham control. Pla, Placebo; R, reperfusion. Ca–Cf, DAB immunostaining for p-β-catenin in hippocampus CA1 at 24 h after global cerebral ischemia. Results are representative of staining observed in four individual animals per group. D, E, E2 prevents cerebral ischemia-induced reduction of nuclear β-catenin levels in hippocampus CA1 after global cerebral ischemia. Values are mean ± SEM of determinations from five to six individual rats expressed as fold change versus sham control. *p < 0.05 versus sham control; # p < 0.05 versus the Pla group at the same time point. Fa–Fi, Confocal analysis of NeuN and β-catenin immunostaining in hippocampus CA1 at 24 h after global cerebral ischemia. Results are representative of staining observed in five individual animals per group (magnification, 40×). Scale bars, 50 μm.