Figure 9. The principle of the PROTAC approach.
Targeted degradation of proteins is achieved by attracting an E3 ubiquitin ligase through a heterobifunctional molecule, the so-called PROteolysis Targeting Chimeric molecule (PROTAC)
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.