Table 4. ECG changes during treatment (baseline vs end of treatment), by treatment.
Intraindividual changes at baseline | HAT Stage 1 | HAT Stage 2 | ||||
DB289 | Pentamidine | p-value | Melarsoprol | DFMO | ||
(N = 526) | (N = 229) | (N = 177) | (N = 47) | (N = 9) | ||
Repolarisation changes (%) | ||||||
appearance/aggravation | 1.9 | 5.7 | 4.5 | 0.300 | 29.8 | 44.4 |
disappearance/improvement | 1.5 | 13.1 | 9.6 | 0.138 | 12.8 | 11.1 |
Low voltage (%) | ||||||
appearance | 0.2 | 2.2 | 1.7 | 0.363 | 6.4 | 0 |
disappearance | 0 | 1.3 | 1.7 | 0.625 | 4.3 | 0 |
AV block I (%) | ||||||
appearance | 1.3 | 2.6 | 1.1 | 0.190 | 0 | 0 |
disappearance | 0.8 | 1.3 | 0.6 | 0.872 | 2.1 | 0 |